|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Čes. a Slov. Farm., 51, 2002, No. 3, p. 150-153|
Studies of Local Anaesthetics
CLIX. HPLC Separation of 1-Methyl-2-piperidinoethylesters of Alkoxyphenylcarbamic Acid
RENČOVÁ M., ČIŽMÁRIK J., LEHOTAY J., HROBOŇOVÁ K.
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava Katedra analytickej chémie Chemicko-technologickej fakulty STU, Bratislava
The paper employed R- and y-cyclodextrins as chiral stationary phases in HPLC, the mobile phases being polar organic solvents. Enantiomers of alkoxysubstituted esters of phenylcarbamic acids (local anaesthetics) were separated and various effects on the process of separation were examined. Primarily the effects of the composition and concentration of organic solvents and the effect of the presence of ionic modifiers in the mobile phase were investigated. The conditions of separation of the enantiomers of phenylcarbamic acid derivatives were found. Interactions influencing separation of enantiomers are also discussed.
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