|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Čes. slov. Farm., 2004; 53, 187–191|
A Study of the Stability of Dioxopromethazine by HPLC Method
CAPKOVA Z., HUDECOVÁ T.1, HATRÍK Š.1, HAVRÁNEK E.1, VITKOVÁ Z.
Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava 1Katedra farmaceutickej analýzy a nukleárnej farmácie Farmaceutickej fakulty UniverzityKomenského, Bratislava
Dioxopromethazine began to be used in therapy as a modern antihistamine agent in the 1970s.
A dioxopromethazine-containing ophthalmic instillation and a gel were employed until the end of
the 1990s. The paper deals with the examination of the stability of the drug dioxopromethazine in
aqueous solutions and the ophthalmic instillation Promefrin® stored under different conditions.
High-performance liquid chromatography with spectrophotometrical and electrochemical detection
and HPLC connected on-line with mass spectrometry were employed for analysis. Dioxopromethazine
in aqueous solutions and in ophthalmic instillations stored in direct sunlight was found not to
be stable. However, the cover of the ophthalmic instillation, a brown-glass prescription bottle, and
observation of storing conditions sufficiently protect the active ingredient from decomposition
Order this issue
|BACK TO CONTENTS|
|| HOME PAGE | CODE PAGE | CZECH VERSION ||
|© 1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ|
|Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o.|