Background. The aim of study, which was supported by grant IGA MZ ČR NR 7814-3, was to
determine sensitivity of serum tests APRI, test of liver fibrosis according Forns and α2macroglobulin in
detection of liver fibrosis.
Methods and Results. The cohort study included 30 patients with chronic hepatitis C, all were infected
HCV genotyp 1a or 1b. Liver biopsy specimen was evaluated by one pathologist and liver fibrosis was
classified according Battes–Ludwig.
Conclusions. Statistically significant correlation of APRI and α2macroglobulin with the stage of fibrosis
was identified; while there was no statistically significant sensitivity of Forns test of liver fibrosis.
liver fibrosis, non-invasive detection, chronic viral hepatitis C.