Background. Autoimmune thyropathies belong to the most frequently occurring autoimmune
endocrinopathies. Autoimmune thyropathies occur either independently or linked to known
polyglandular syndromes of type I–III.
Methods and Results. During the last decade, we observed a group of patients with autoimmune
thyroiditis, in which autoimmune endocrinopathies were mutually associated and named the symptoms
of this group „polyglandular activation of autoimmunity“. The frequency of the occurrence of
autoantibodies against other endocrine organs in this group was determined and the most frequent was
the occurrence of the autoantibodies against steroid producing cells – anti-ovary 28 %, anti-adrenal 23
%, anti-testes 12 %. Considering the most frequent occurrence of autoantibodies against steroid
producing cells, attention has been paid namely to patients with autoimmune thyroiditis and a concurrent
occurrence of anti-adrenal autoantibodies. In the foreground of the clinical picture of these patients were
dysregulations on the metabolic and circulation levels together with symptoms of discomfort (subfebrile
condition, arthralgia and fatigue). Heavy fatigue of these patients was linked to the changes of levels and
mutual ratio of melatonin and serotonin and regarding autoantibodies, mainly autoantibodies against
steroid producing cells, namely against the particular cells of the layers of adrenal cortex played a role.
Conclusions. The presence of autoantibodies influenced also the functional response, namely the
ACTH/cortisol ratio. Autoantibodies detected were not anti-21-hydroxylase autoantibodies, typical for
autoimmune polyglandular syndrome II, but antibodies against antigens of other molecular weight.
autoimmune thyroiditis, polyglandular activation of autoimmunity, autoimmune
polyglandular syndrome, autoantibodies.