Pancreatic Cancer and Diabetes Mellitus
Krechler T., 1Novotný J., Zeman M., 2Krška Z., Švestka T., 2Šváb J., Lukáš M., 3Filipová R., Žák A.
IV. interní klinika 1. LF UK a VFN, Praha 1Onkologická klinika 1. LF UK a VFN, Praha21. chirurgická klinika 1. LF UK a VFN, Praha 21. chirurgická klinika 1. LF UK a VFN, Praha 31. LF UK, Praha
Background. The aim of the present study was to evaluate the relationship between Pancreatic Cancer and Type 2
Diabetes Mellitus, which represents a higher risk of many human tumors. In patients with Pancreatic Cancer, Type
2 Diabetes Mellitus occurs approximately in 30 %.
Method and Results. Fifty patients with newly diagnosed Pancreatic Cancer were analysed in a retrospective pilot
study where the staging of the tumor and the case history of the patients were studied. This data were compared in
three groups of patients: the control group without diabetes, one with Impaired Fasting Glucose, and patients with
Diabetes Mellitus. Incidence of DiabetesMellitus and that of Impaired FastingGlucose were also followed in patients
with Pancreatic Cancer and Colorectal Cancer. The retrospective study confirmed the late diagnosis of Pancreatic
Cancer. The tumors were actually in clinical stage IV in 50 % of the patients. Diabetes Mellitus was present in 34 %
of patients with Pancreatic Cancer; in 44 % of these patients the Impaired Fasting Glucose was also diagnosed while
the normal glucose status was seen in 22 % of patients. Incidence of Impaired Fasting Glucose and that of Diabetes
Mellitus in groups of patients with Pancreatic Cancer and Colorectal Cancer was studied. Diabetes Mellitus was
present in 12,5 % patients with Colorectal Cancer.
Conclusions. In spite of modern diagnostic methods, the early diagnosis of Pancreatic Cancer remains a great
problem. Incidence of Diabetes Mellitus in patients with Pancreatic Cancer was significantly higher in comparison
with the Colorectal Cancer group (P0,01). A significant number of patients with Impaired Fasting Glucose were also
present in the group with Pancreatic Cancer. Analysis of the relationships between Pancreatic Cancer and Impaired
Glucose Metabolism could contribute to the early diagnosis of this serious malignant disease.
pancreatic cancer, diabetes mellitus, impaired fasting glucose, staging of the tumor, colorectal