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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
| Journals - Article | |
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| Česky / Czech version | Čes. - slov. Pediat., 58, 2003, No. 7, p. 418-420 |
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Polymorphism of MTHFR and MTRR in Czech Patients
with Cardiovascular Diseases and Stroke Matalon R., Rady S., Szucs K., Matalon P., Hyánek J., Šebesta P.,Matoušková J., Vondráčková N., Pejznochová H., Dubská L., Přindisová H., Dvořáková J., Loučka M., Martiniková V., Šlancová M. Dept. Pediatrics, Div. Genetics, University of Texas, Galveston, USA Metabolic Unit on Dept. Clinical Biochemistry, Dept. Vessel Surgery, Dept. Cardiology, Dept. Neurology and Dept. Radiodiagnostics of Hospital Homolka, Prague Institute Physics and Statistics, School of Chemical Technology, Prague |
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Summary: Blood from 27 Czech patients with cardiovascular disease and stroke, who also had hyperhomocysteinemia,
was analyzed for methylene tetrahydrofolate reductase (MTHFR) polymorphism. These patients had significantly
higher incidence ofMTHFR 677 C > T polymorphism compared to controls (p < 0.001). The incidence theMTHFR
1298 A > C and methionine synthase reductase (MTRR) 66 A > G polymorphism was not significantly different.
The hyperhomocysteinemia in 70% of these patients was reversible by folate supplementation.
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