Schizophrenia is a clinically heterogeneous state without clearly defined pathogenesis. This limits the classification
approaches with consequent lack of ability for individual treatment strategies. It becomes evident that hippocampus
is a key structure in the neuropathology of schizophrenia and a concept of hippocampal reduction as an
endophenotype of schizophrenia was established. The biggest support came from MRI volumetric studies. Despite
that, due to some inconsistent findings, clinical consequences of hippocampal shrinkage are not yet clear.
Contemporary methods of brain imaging (computation morphometry, voxel-based morphometry) could help us to
outline the concept of schizophrenia and to clarify the clinical consequences of brain structure changes.
schizophrenia, endophenotype, morphology, volumetry, computational neuroanatomy.