Background. Parathyroids dysfunction is a key disorder in the spectrum of renal osteopathy, occurring after renal
transplantation and, occasionally, after parathyroidectomy. In our subjects, dysfunction is understood as plus or
Methods and Results. Parathyroidectomy as the primary procedure was performed in 179 patients for all types of
hyperparathyrodism. In 70 % of cases the secondary hyperparathyroidism was treated, believed to be the most severe
condition. Present assessment was focused on postoperative parathyroid hormone levels (pg/ml) in three groups of
patients (n=92). Group 1 with parathyroid gland autoimplants following total parathyroidectomy; Group 2 after
partial or subtotal surgery; Group 3 after autologous implantation of cryopreserved parathyroid glands in severe
hypoparathyroidism. Group 1 (32 dialysis and 9 non-dialysed patients): 228.9 vs 85.9 pg/ml; ns; hypofunction in
50 % and in 33 % respectively, afunction in 12.5 % of dialysed patients, in non-dialysed patients it was not detected.
Group 2 (25 dialysis and 24 non-dialysed patients): 603.3 vs 169.8 (pg/ml); p=0.01; hypofunction in 16 % and in
8% respectively, afunction was not detected. Complete groups 1 and 2 of patients: 197.5 vs 382.3 pg/ml (p=0.0016).
Dialysed patients in Group 1 and 2: 228.9 vs 603.3 pg/ml (p=0.007); non-dialysed patients: 85.9 vs 169.8 pg/ml; ns.
Group 3 (15 dialysed patients): 63.0; hypofunction and afunction in 40 %. This group (63,0 pg/ml) vs Groups 1 and
2 of dialysed patients (p=0.031 and 0.0004), respectively. Basic laboratory findings before operations of tertiary
hyperparathyroidism were shown.
Conclusions. After total parathyroidectomy with parathyroids autoimplantation, parathyroid hormone is acceptable
to dialysis and non-dialysis patients. Partial parathyroidectomy prevents development of hypoparathyroidism. It is
associated, however, with a risk because of hyperparathyrodism recurrence. Cryopreserved autologous parathyroids
reach lower parathyroid levels compared with „fresh“ parathyroid tissue autoimplants. Parathyroidectomy after
successful renal transplantation may be inicated.
parathyroid hormone, hyperparathyroidism, hemodialysis, renal transplantation, parathyroidectomy,
hypoparathyroidism, parathyroid gland implantations.