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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
| Journals - Article | |
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| Česky / Czech version | Čes. a Slov. Farm., 49, 2000, No. 4, p. 204-206 |
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Anti-Inflammatory Activities of Copper(II) and Zinc(II) p-Cresotates Dihydrates SOKOLÍK J., TUMOVÁ I., BLAHOVÁ M., DANKOVÁ M., ŠVEC P. Katedra chemickej teórie liečiv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava |
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Summary: Using rat paw dextran-induced and carrageenan-
induced edemas, the antiedematous activities of
dihydrate of diaquatetrakis(p-cresotato)dicopper(II) complex (CupC) and diaquabis(p-cresotato)zinc(II) complex (ZnpC) were assayed plethysmometrically. Dihydrate of diaquabis(salicyla-
to)copper(II) complex (CuS) and diaquabis(salicylato)zinc(II) complex (ZnS) were used as standards
of comparison. All compounds were applied i.p. in a single dose of 50 mmol/kg body weight (calculated
for the RCOO-fragment) 30 min before injecting the irritant. The antidextran/anticarrageenan
activities of the species (expressed as a mean edema reduction) were found: CupC 46/74 % – ZnpC
50/26 % – CuS 71/52 % – ZnS 63/10 %. The relationships between the coordination-chemical
properties and the biological effects of the corresponding complexes are discussed.
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