The trend of current research is not only to obtain a complete characterisation of the cause of inception of tumor
proliferation, but in particular to characterize in detail multi-degree cascades of the metastatic process. Precise
description of the effector genes and their protein products which influence individual processes of the metastatic
cascade, is of great significance not only for the early diagnosis of the possible tumor invasion into its immediate
environment and the creation of distantmetastases, but particularly for the development of new therapeutic procedures
which will help to change from empirical to causal treatment. In practice this means a shift from those therapeutic
procedures which lead only to simple blocking of cell division or cell growth, to addressing the individual stages of
tumor development (correction of genetic defects in tumor cells, inhibition of the metastatic cascade, inhibition of
angiogenesis and apoptosis, etc.). The article characterizes the biological activity of tumors in connection with the
metastatic process in colorectal carcinoma.
metastatic process, colorectal carcinoma, markers of biological activity.