The intestinal mucosa represents important primary interface with the external environment. The mucosal immunity
posses the ability to differentiate between non-pathogenic microbial agents (non-inflammatory immune reaction) and
pathogens (inflammatory immune response). The defence mechanisms of intestinal mucosa due to extensive nonadaptive
and adaptive immune reactions facilitate both inductive and effector side of immune response. The oral tolerance
is dependent on the mucous intestinal immunity and modulates the systemic immune reactivity.
enterocytes, Paneth cells, mucous immunity, defensins, M cells.