Chalcones and their heterocyclic analogues possess a number of biological effects. Their antifungal
effects were reported in the previous communication (Opletalová V., Šedivý D.: Čes. a Slov. Farm.
48, 252 (1999)). The present review is devoted to the antibacterial activity of these compounds. For
antibacterial activity, the presence of the enone aggregate in the molecule is important. Hydroge-
nated analogues are less effective or ineffective, saturated brominated analogues are effective
probably after a metabolic transformation into unsaturated a-bromochalcone. In the rings, substi-
tution with a hydroxyl is advantageous, in some cases also substitution with a lipophilic substituent,
e.g. a halogen or an alkyl, proved to be advantageous. On the other hand, substitution with amino
groups often results in a decrease in effectiveness. Effectiveness of chalcones and their derivatives
against gram-positive microorganisms is usually higher than against gram-negative bacteria. Some
analogues, however, inhibited also the growth of gram-negative strains. With regard to increased
incidence of tuberculosis in recent years, antimycobacterial effectiveness of chalcones and their
derivatives is especially interesting.
chalcones – heterocyclic analogues of chalcones – antibacterial activity
– antimycobacterial activity