Several systemically administered drugs with antimicrobial effect have undesirable phototoxic effects.
This group includes some antibiotics (e.g., tetracycline, fluorochinolons, and also macrolids), sulphonamides
and related chemotherapeutics, antimycotics, tuberculostatics, antiviral drugs and antimetabolites.
Doctors should know the phototoxic effect of those drugs in advance, because of the possible time shortage
they might have when they prescribe the drugs. The first condition is to obtain the relevant personal
history data, and in case the phototoxic reaction develops, to terminate the unsuitable drug, to change
it for another, to administer antihistaminics, sometimes corticoids, prevent exposition to sun, and
administer local anti-inflammatory dermatological drugs.
phototoxicity, photosensitization, UV light, UVA, UVB, antimicrobial drugs.