The importance of mycotic infections of the skin and its adnexa has a rising trend. The causal agents are not only
dermatophytes and candidae but to an increasing extent opportune fungal microorganisms. Most frequently these
diseases develop during intense immunosuppressive treatment, e.g. in oncological, oncohaematological diseases and
in developed AIDS syndrome. In addition to the reduced defence capacities of the organism favourable conditions
are created e.g. by antibiotic treatment, treatment with female hormones, unsuitable clothing, obesity, a certain part
is played also by occupational predisposition.
Treatment of onychomycoses is complicated and difficult. Before griseofulvin was available there was only surgical
ablation and treatment with keratolytics. At present a number of substances with marked fungistatic effects is
available. The author mentions: griseofulvin, ketoconazole, fluconazole, itraconazole (azole derivatives), allylamines
(terbinafine-Lamisil). He discusses the mode of administration, dosage and undesirable effects. The recent antimy-
cotics are ciclopiroxolamines (Batrafen) and amorolfin (Loceryl) in the form of lac.
dermatophytoses, immunosuppressive agents, cytostatics, X-ray irradiation, fungicides, undesirable