Desloratadine was determined in two dosage forms (tablets and syrup) with the use of the method of capillary
isotachophoresis. Several electrolyte systems of varying composition and varying pH were tested. Two
electrolyte systems were selected for the validation of the method and determination of desloratadine in real
samples. In both electrolyte systems, the precision, correctness, linearity, robustness, and selectivity of the ITP
method were evaluated. The pre-treatment of the sample prior to analysis consisted in dissolving and diluting
the pertinent desloratadine-containing dosage form with demineralized water to the required concentration. This
pre-treated sample was fed directly to the apparatus.
capillary isotachophoresis – desloratadine – tablets – syrup - validation