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  Česky / Czech version Čes. a Slov. Farm., 50, 2001, No. 5, p. 238-242
 
Cytotoxic and Genotoxic Activity of Selected Preservative Compounds for Cosmetics 
JANTOVÁ S., HOJEROVÁ J., HANUSOVÁ B., MIKULÁŠOVÁ M. 

Katedra biochémie a mikrobiológie Chemicko-technologickej fakulty Slovenskej technickej univerzity, Bratislava Katedra mlieka, tukov a hygieny požívatín Chemicko-technologickej fakulty Slovenskej technickej univerzity, Bratislava
 


Summary:

       Cytotoxic effects of the preservative compounds for cosmetics JMAC TD, Bronopol, CA 24, and Euxyl K100 esere studied. Bronopol demonstrated the highest Cyotoxic effect on the proliferation of V79 and VH10 fibroblast cell unes - the ICioo values being 10 mg/1 during the whole experiment. The preservatives CA 24 and Euxyl K100 showed 4-times and 5-times smaller Cyotoxic activity than Bronopol ICioo = 42 or 50,3 mg/1). The preservative compounds on silver chloride ions JMAC TD manifested the lowest cytotoxicity of the preservatives tested (ICioo = 150 mg/1); 15-times smaller than Bronopol, 3,5-times smaller than CA 24 and 3-times smaller than Euxyl K100. The biocide JMAC TD did not exhibit mutagenic effects on the bacteria Salmonella typhimurium TA 98 and TA 100.

        Key words: cytotoxicity - genotoxicity - in ~itro methods - preservatives - cosmetics
       

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