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  Česky / Czech version Čes. slov. Farm., 52, 2003, No. 3, p. 119–125
 
Chiral Separations of Some Drugs on the Basis of Macrocyclic Antibiotics in HPLC, SFC and CEC 
ĎUNGELOVÁ J., LEHOTAY J., ROJKOVIČOVÁ T., ČIŽMÁRIK J.1 

Katedra analytickej chémie Fakulty chemickej a potravinárskej technológie Slovenskej technickej univerzity, Bratislava 1Katedra farmaceutickej chémie Farmaceutickej fakulty, Univerzity Komenského, Bratislava
 


Summary:

       Separation of enantiomers by means of high-performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC),and capillary electrochromatography (CEC) is of great importance in pharmaceutical analyses. In recent years, separation of various types of racemates employs most frequently chiral stationary phases based on macrocyclic antibiotics. This class of chiral selectors includes vancomycin, teikoplanin, ristocetin A, teikoplanin without saccharide components, avoparcin, etc.The reviewpaper describes the properties of selected antibiotics, the effect of chromato-graphic conditions on enantioselectivity (effect of the composition of the mobile phase, effect of pH of the mobile phase, effect of temperature), and the study of possible mechanisms of interaction, which play an important role in the separation of enantiomers. Examples of the use of macrocyclic antibiotics in the separation of various compounds by means of the HPLC, SFC, and CEC methods follow.

        Key words: enantiomers – HPLC – SFC – CEC
       

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