Background. A new method of noninvasive assessment of endothelial dysfunction was used in this pilot study. Study
has been set on a. brachialis dopplerometry velocity curves analysis. Index of blood stream deceleration between
the first and second minute of the postocclusion periode was measured on a. brachialis after transient mechanical occlusion
of the forearm – so called Deceleration Index.
Methods and Results. Eighteen patients with so far untreated hypercholesterolemia were involved in our study. Profile
of velocity curves became significantly different after six months of fluvastatin therapy, Deceleration Index increased
from 3 % to more than 7 % (p<0.05). That correlated with LDL-CH levels decrease, but also with the significant
decrease of biochemical markers of endothelial dysfunction (trombomodulin, von Willebrand factor).
Conclusions. The result is corresponding with previously published studies that have proved endothelial function
improvement after statin therapy using another ultrasonographic methods.
endothelium, dysfunction, deceleration index, dopplerometry, fluvastatin.