Gene therapy represents one of the most promising applications of molecular biology and genetic engineering in
medicine. At present its introduction meets series of problems which are of technical, methodological and ethical
nature. Although the research in the field of gene therapy in the Czech Republic is on a good level, there is little
hope that its achievements will be tested in clinical trials in the near future. In the Czech Republic a law enabling
the use of preparations based on the newest biotechnologies in human medicine is missing. Similarly, a production
unit capable of preparing the new gene-based drugs according to the Good Manufactory Praxis is not available and
the State Institute for Control of Drugs has not anyworking group fully qualified for their control. The paper proposes
actions aimed at solving the present unfavourable situation. The fact that the interest of clinicians in gene therapy
is rapidly growing, and that there are signs of increasing interest of public in its achievements, gives good prospects
for the introduction of gene therapy into medical praxis in this country in the not very distant future.
gene therapy, present problems, situation in the Czech Republic.