The paper examines the strength and disintegration time of compacts from the mixtures of two types of Tablettosas,
Tablettosa 70 and Tablettosa 100 with microcrystalline cellulose represented by Vivapur 102. The mixtures
of dry binders were prepared in the ratios of 3:1, 1:1, and 1:3. The effect of two concentrations of the lubricant
magnesium stearate on the strength and disintegration time of compacts was also examined. Tablet
strength increased with higher representation of microcrystalline cellulose in the mixture, and decreased with
higher stearate concentration. The compacts from the mixtures with Tablettosa 100 showed higher strength.
Disintegration time was highest in the compacts with the largest percentage of microcrystalline cellulose, and
longer in the case of the mixtures with Tablettosa 100. Stearate did not exert a negative effect on disintegration
time. In the mixtures of Tablettosas with Vivapur 102 in a ratio of 1:1, the effect of the model active ingredient
acetylsalicylic acid on the above-mentioned properties of tablets was tested. acetylsalicylic acid produced a further
decrease in the strength of compacts and shortened the disintegration time, in more instances in the cased of
the mixtures with Tablettosa 100.
Tablettosa – Vivapur 102 – magnesium stearate –acetylsalicylic acid – tensile strength
of tablets – disintegration time of tablet