Contemporary neuropsychology contributes extensively to the understanding of those aspects of schizophrenia that are directly related to cognition. One of the most influential approaches to schizophrenia is the so-called ‘disconnection hypothesis’. This approach assumes that, in addition to disfunctions in separate brain regions, communication between them is disturbed. The cause of the disconnection may be in anatomical, neurochemical or functional disturbances. This article is aimed at functional disconnection and pays attention to dysfunctional communication between the frontal and temporal lobes. It also outlines the development of the so-called functional fronto-temporal disconnection and its hypothetical connection to various cognitive dysfunctions and psychiatric phenomena. The disturbed communication between frontal and temporal regions may cause memory, speech or executive dysfunctions. The fronto-temporal disconnection could also explain how some auditory hallucinations arise. It is not clear whether this disconnection could be one of the trait markers of schizophrenia.

        Key words: fronto-temporal disconnection, schizophrenia, cognition, frontal cortex, temporal cortex.