Peptic ulcer is the most frequent cause of upper gastrointestinal bleeding. Its mortality remains high due to increasing age of referred patients and their complex comorbidity. These patients are subject of multidisciplinary care and endoscopy is an important part of the process. The initial finding at endoscopy is not the most important prognostic factor compared to hemodynamic status, age and comorbidity at initial presentation. The most efficient endoscopic treatment is combination technique using injection and thermal coagulation. Use of hemoclips showed promising results as well. Intravenous proton pump inhibitors are widely recommended. High volume centers with multidisciplinary team and expertise show best results regarding mortality, surgery rate and lenght of hospital stay.

        Key words: haemodynamic status, injection, thermal coagulation, hemoclips