Aim: To determine, whether the immediately originated allergic reaction of conjunctivas may be treated with local H1 antihistaminic drugs in a monotherapy (Allergodil gtt, Emadine gtt). Group and Methods: The group included 30 patients at the age of 17 to 40 years at the mean age of 33.2 years, where chemosis and hyperemia of bulbar conjunctiva originated suddenly aswell as edemaof eyelids.Thereportedsubjectivesymptoms were itching,burningsensation in theeyes,lacrimation,andthefeelingofpressure under the eyelid. Local treatment with azelastin (Allergodil gtt. oph., Pliva), was applied in 15 patients, the other 15 patients were treated locally with emedastin (Emadine gtt. oph., Alcon) at the dose of one drop twice daily into the conjunctival sac of both eyes. The time of onset of the therapeutic effect and the disappearance of subjective symptoms and objective signs were observed. Results: The disappearance of subjective symptoms after the start of therapy developed within 20 minutes after Allergodil gtt and within 5 minutes after Emadin. Subjective complaints disappeared in the range of 86 – 100 % after Allergodil gtt and in the range of 90 – 100 % after Emadin gtt. A substantial diminution or even complete disappearance of objective symptoms developed in 74 – 80 % cases after the treatment with Allergodil gtt and in 80 – 87 % subjects after Emadin gtt. Conclusion: The investigated local H1 antihistaminic drugs proved to be effective in monotherapy of acute phase of allergic conjunctivitis. The drugs influence subjective complaints faster and more efficiently than the objective signs. The therapy of objective manifestations requires longer period of time for the effect to develop.

        Key words: acute allergic conjunctivitis, local H1 antihistaminic drugs, azelastin, Allergodil, emedastin, Emadine