The authors describe a non-Hodgkin malignant large-cellBlymphomawith ample lymphocytes in a female patient with foci in the left breast and right orbit, with suspect skin foci and enlarged nodes in the mediastinum as revealed by computed tomography. In the differential diagnosis the authors reflected according to the course of the disease in addition to malignant lymphoma also on orbitocellulitis or a pseudotumourof the orbit.Theremarkable feature is thatthepatienthadalreadytreatment on account of a multiple myeloma. The authors emphasize comprehensive treatment of the patient and the necessity of consultations with specialist of other medical disciplines associated with this disease. After radiotherapy total regression of the orbital finding occurred in the patient.

        Key words: malignant lymphoma of the orbit, radiotherapy, comprehensive treatment