The aim of the cohort retrospective study was to analyze and evaluate the influence of certain factors (age, profession, smoking) on the characteristics and the incidence rate of the upper respiratory tract diseases (URTDs) in the occupational contact with ammonium. Subjects were 180 men, divided into 3 professional groups. The average shift concentrations of ammonium were measured in the permanent work places and individually by personal passive dosemeters. The URTDs were classified into 15 groups according to localization and the stage of the inflammatory process. The relationships "time-response" and "dose (concentration)-response" were determined. The factor "cumulative exposure" was used in order to evaluate the actual noxious effect of NH3 on the mucose of the upper respiratory tract (URT). There was a statistically reliable difference found in the incidence rate of atrophic rhinitis, hypertrophic pharyngitis and laryngitis, and neoplasms of the URT in the workers with the highest cumulative exposure. For this group relative risk was 4.00, 2.22, 3.20 and 4.00, respectively, with 95% CI. The "cumulative exposure" factor gives the best proofs for the toxic effect of ammonium and a possibility for assessment of the relative risk.

        Key words: ammonium, occupational contact, upper respiratory tract diseases, relative risk