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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 49, 2003, No. 7, p. 576 - 579 |
First Experience with the Therapy of Chronic Hepatitis
C in a HIV-positive Patient Husa P., Snopková S., Chalupa P. Klinika infekčních chorob Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta doc. MUDr. Pavel Chalupa, CSc. |
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Summary: A 30 years old man originating from Ukraine was infected by the human immunodeficiency virus
(HIV) and virus of hepatitis C (HCV) due to injection administration of drugs of abuse in his own
country before coming to Czech Republic. He was infected by genotype 3 of HCV and the infection
became chronic. Under the influence of a three-combination anti-retrovirus therapy his conditions
related to HIV infection became stable and it proved to be possible to apply a combined
treatment by alpha-interferon and ribavirin at commonly used doses for the period of 12 months.
In the course of therapy the HCV nucleic acid (HCV RNA) disappeared from serum and serum
activity of alanine aminotransferase (ALT) became normal. However, two months after the therapy
ended a relapse of the disease occurred - HCV RNA reappeared in serum and ALT activity
increased. The therapy was well tolerated. A rapid decrease of hemoglobin level during the first
four weeks of therapy was stopped by reduction of ribavirin dose.
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