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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Transfuze Hematol. dnes, 14, 2008, No. 1, p. 28–33. |
RNA vaccine – clinical studies Dudová S.1,2, Michálek J.1,2,3, Hájek R.1,2,4 1Laboratoř experimentální hematologie a buněčné imunoterapie, Oddělení klinické hematologie, Fakultní nemocnice Brno, 2Lékařská fakulta Masarykovy Univerzity Brno, 3Fakultní nemocnice Brno, 4Interní hematoonkologická klinika, Fakultní nemocnice Brno |
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Summary: Immunotherapy using dendritic cells develops is considered as one of the possible treatments of patients with tumour
diseases in the last years. These antigen presenting cells play important role in the induction of primary immune reaction
on specific antigens. Data from in vitro studies of the efficiency of vaccines of dendritic cells loaded with individual
tumour RNA provides promising information and the base for further dendritic cell vaccines development.
Impact of RNA-transfected cell vaccine on T-cell immunity and preparation of therapeutic anticancer responses
was first studied on murine models and acquired results subsequent clinical studies on humans. Following survey
summarizes studies focused on the use of RNA vaccines in tumour patients.
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