Aim of the study: The evaluation of combined and miscellaneous vulvovaginal infections incidence and their treatment with combined vaginal products containing nifuratel and nystatin. Design: Prospective study. Setting: Gynecologic outpatient department LEVRET, Prague; Laboratories of Microbiology AescuLab, Prague. Methods: 70 consecutive patients were examined with complaint of vaginal fluor and/or pruritus. We established macroscopic features of fluor, pH, amine test and mounts stained with Giemsa and Gram. We qualified the cases with more diagnostic criteria (mycosis, lactobacillosis, anaerobic vaginosis, aerobic vaginitis) as combined infection, those with no diagnostic criteria as miscellaneous. We treated all patients with vaginal tablets nystatin + nifuratel (Macmiror complex). We prescribed clotrimazol cream, if pruritus was present. We evaluated withdrawals of symptoms and relapses during 3 months after treatment. Results: Combined infection was found in 21 patients from 70 (30 %). The most frequent combination was that of mycosis and aerobic vaginitis (13/70, 18.6 %) or mycosis and anaerobic vaginosis (4/70, 5.7 %); 11 patients fulfilled criteria of no diagnosis. We concluded them as „miscelaneous”. The treatment was successful in all cases, 10 women relapsed in 3 months. Conclusions: Combined vaginal infection findings are present very often (30%), likewise miscellaneous ones (15%) occur. The treatment of these women in successful with vaginal tablets with nystatin + nifuratel.

        Key words: vaginitis, nystatin, nifuratel