Summary:
In the year 2005, Chang and Cambell described unusual reaction of the iris
during the cataract surgery in patients treated with tamsulosine. This was
named as IFIS, an acronym for the Intraoperative Floppy Iris Syndrome. In its
advanced stage, the syndrome is characterized by insufficient mydriasis before
the surgery, narrowing of the pupil during the surgery, its impossible dilatation
during the surgery by means of stretching, unusual elasticity of the pupilar
margin, surging and fluttering iris with tendency to prolapse. The same
manifestations we observed in our patients and we confirm the direct
connection with tamsulosine hydrochloride treatment. Tamsulosine is the
antagonist of alpha 1A adrenergic receptors whose are present, except in the
smooth musculature of the prostate gland and the urinary bladder, in the iris
dilator as well. At the same time we observed this syndrome rarely in some
patients not using tamsulosine. In most cases, these patients were treated with
antipsychotic drugs.
Key words:
alpha 1 A receptors, IFIS – intraoperative floppy iris syndrome,
tamsulosine hydrochloride
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