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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 49, 2003, No. 3, p. 227 - 233 |
Specific Features of Haematopoiesis and Haemostasis in Advanced
Age Kubešová H.1, Penka M.2 1Klinika geriatrie, ošetřovatelství a praktického lékařství Lékařské fakulty MU, Brno, přednosta doc. MUDr. Hana Kubešová, CSc. 2Oddělení klinické hematologie FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Miroslav Penka, CSc. |
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Summary: The ageing process affects also haematopoiesis and haemostasis and these changes can have a far
reaching effect on other organ systems and their function. The authors decided therefore to
present a review on involutional changes on the formation and function of blood elements and the
system of blood clotting. The review is divided into description of changes in the bone marrow
and explanation of hitherto known facts on the pathophysiological background of these changes.
Furthermore the authors deal with changes in the peripheral blood stream and their mutual
relations with administered drugs, diseases under way, reactions to external stimuli such as
immunization etc.
In the second part of the review the authors describe changes of haemocoagulation , emphasize
the tendency of hypercoagulation and the mutual relationship of the development of atherosclerotic
changes and hypercoagulation trends and their pathophysiological background. Attention is
paid to thromboembolic disease and its increasing risk in elderly patients incl. the possible late
manifestation of congenital defects of coagulation inhibitors. The authors mention also the influence
of lifestyle and dietary factors on the coagulation activity in old age. They analyze in detail
possibilities and pitfalls of prophylaxis of thromboembolic disease in elderly patients and the
risks of haemorrhagic complications of different operations.
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