The smoking influences all organ systems of human body including gastrointestinal tract: it increases the risk of many gastrointestinal disease (eg. tumours of oral cavity, oesophagus and pancreas, peptic ulcer, biliary stones, chronic pancreatitis) and deteriorates the course of that diseases and theirs treatment. Considering smoking relationship there is an interesting opposite influence of tobacco abuse in inflammatory bowel disease, ulcerative colitis and Crohn’s disease.

        Key words: smoking – risk of gastrointestinal tract disease