Despite being discovered long time ago – in the 50th of the previous century, the existence of free cell human DNA in different body fluids is getting its importance only in the last decade. The presence of the free cell human DNA in different body fluids gives us new opportunities in diagnosis and/or in follow up of different diseases or clinical settings. Being a relatively new method, even its methodology is waiting to be standardized, as well its clinical role under different clinical courses. The aim of this text is to review the current literature concerning free cell DNA importance under different clinical situations.

        Key words: free cell DNA.