Purpose: Peliosis of the spleen is very rare disease diagnosed mainly histologicaly. The ethiopatogenesis is still unknown and various factors can play the important role (steroids, chemotherapy, chronic infection, hematology disease etc.). Authors present the case of peliosis of the spleen which was combined with suprarenal adenoma. Method: The splenectomy for the large spleen with suspection from lymfoma was done in hypertonic patient with normocytic normochromic anaemia. During operation the left suprarenal adenoma was revealed and epinefrectomy was performed. The diagnosis of peliosis of spleen was done by histological examination. The hypothesis of the connection between hormonal activity of the suprarenal adenoma and development of the peliosis was expressed. Unfortunately the suprarenal adenoma was not diagnosed before operation and so plasma hormone levels were not evaluated. Results: The postoperative course of patient was without complications and patient was discharged 8th postoperative day. One year after operation the patient is in the good health condition. The hypertension is corrigated on the lower dosage of antihypertensive medicaments. Conclusions: It is probable, that the suprarenal adenomacould play the important role in the ethiopatogenesis of peliosis of the spleen in our case.

        Key words: splenic peliosis – suprarenal adenoma