Skeletal disorders represent ever-rising problem. Such diseases are of the highly heterogenous origin and for their verification the laboratory diagnostic of metabolic skeletal changes cannot be omitted. Increasing knowledge on the physiology and pathophysiology of the bone tissue metabolism and the use of new laboratory methods can improve the diagnosis and treatment of such critical states. The article gives an overview of contemporary possibilities of the laboratory diagnostic of metabolic skeletal changes. The significance, advantages, disadvantages and possible risks in evaluation of individual osteomarkers are presented.

        Key words: skeleton, bone tissue metabolism, laboratory diagnostic, osteomarkers.