This review focuses on the problems and questions regarding the treatment of septic patients using coagulation inhibitor concentrates from the haematologist’s point of view. Currently available published data are reviewed and summarised and on its basis recommendations for the administration of commercially available coagulation inhibitor concentrates (mainly AT, PC, aPC and heparins) are formulated.

        Key words: sepsis – coagulation – antithrombin – heparin – protein C – bleeding – thrombosis