Glutathione-S-transferases in the Urine: New Sensitive Met-
hods for Detection of Renal Tubular Dysfunction
Rajnič A., Ďurovcová E.
IV. interná klinika, LF UPJŠ a Fakultná nemocnica Louisa Pasteura, Košice, Oddelenie klinickej biochémie, Fakultná nemocnica Louisa Pasteura, Košice |
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Summary:
Urinary glutathione-S-transferases (GSTs) in the urine is a new sensitive method for detection of kidney
damage. In general, GSTs offer the following possibilities: aGST is a very specific and sensitive marker of
proximal tubular injury. It is rapidly released in the event of tubular injury, sooner than serum markers of renal
injury. a-GST has been shown to be an excellent marker of tubular injury resulting from a variety of nephrotoxic
drugs, such as Cyclosporin and aminoglycosides, or anoxic stress resulting from transplantation or intra-opera-
tive ischaemia. p-GST is a marker of distal tubular injury. Previously, it has been difficult to monitor this
important tissue non-invasively. Little has been published on toxic, or other, damage to the distal tubules. This
may be due to previous difficulties in monitoring this tissue, but it makes it a stimulating esciting area for
research. For example, infection and transplant rejection often affect predominantly the distal tubules. Urinary
a- and p-GST levels may indicate renal effects in advance to serum markers such as creatinine. By measuring
both a and p-GST it is possible to identify injuried areas of the renal tubule.
Key words:
urine, glutathione-S-transferase, renal tubular damage, clinical diagnosis.
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