The authors performed an open label pilot trial to assess efficacy and tolerability of 40 mg of parecoxib in comparison with standard premedication (midazolam and pethidine) before colonoscopy. Assessment was performed by evaluation of a simple questionnaire answered by patients as well as by endoscopists. There was no statistically significant difference between parecoxib alone and midazolam plus pethidine group as to the intensity of pain during procedure. Parecoxib, contrary to midazolam, had no effect on patients’ consciousness or respiratory activity. Therefore, parecoxib seems to be an efficacious and welltolerated option for premedication before colonoscopy.

        Key words: premedication, analgetic effectiveness, colonoscopy