Thirteen patients with Langerhans cell histiocytosis (LCH) have been treated in our department during the last 15 years. Tree of them with multifocal bone recidives were threated with 2-chlordeoxyadenosine as an initial therapy. These three patients are followed up for more then 24 months and they are without relapse of this disease. The 2- chlordeoxyadenosine is very efficient in multifocal bone form of LCH and has potential to reach long remission. Therefore in a case of aggressive multifocal disease we would prefer 2-chlordeoxyadenosine therapy as therapy of the first choice.

        Key words: Langerhans cell histiocytosis, 2-chlordeoxyadenosine