Aim: The aim of this study was to evaluate surgical options and therapeutic results of the large intestine perforation treatment, conducted by the authors‘ team. Methodology: During a four-year-period, a retrospective study including 53 patient subjects suffering from the large intestine perforation followed by peritonitis was conducted by the authors‘ team. The peritonitis- related risks were classified according to the Mannheim Peritonitis Index – the MPI score. Results: The mean value of the MPI score reached 24.4 points in the assessed group. The total mortality rate reached 18.9% in the assessed group. The MPI score was significantly lower in the surviving patients group, compared to the exited patients group. Furthermore, theMPI score was significantly lower in the group of patients suffering from benign disorders of the large intestine, compared to the group of patients with malignancies. Resection with primary anastomosis (RPA), as a surgical treatment method, was successful in 32.1% of all cases in the group and in 73.9% of the patients treated using RPA. Conclusion: In indicated cases, the RPA method remains the appropriate surgical approach for the patients with the large intestine perforation, even when diffuse peritonitis concurs. The MPI score represents a simple and sufficiently reliable assessment system for the patients suffering from the large intestine perforation.

        Key words: the large intestine perforation – peritonitis – Mannheim Peritonitis Index