The authors present the case report of a woman with autoimmune polyglandular syndrome type 2. The authors point out the broad issue concerning multiple manifestations of this disorder. The autoimmune process may involve multiple organs and tissues. Diagnosis and treatment requires the cooperation of various specialists and is complicated due to the fact that the autoimmune process may proceed asymptomatically or in a sub-clinical form for a long time. The disease necessitates life-long treatment, and in some cases may lead to complete disability. The generál practitioner plays a crucial role in identifying the disorder, coordinating the diagnostic process and treatment, and assisting with the sociál consequences of the disease.

        Key words: Autoimmune polyglandular syndrome type 2, general practitioner, health-social aspects.