Safety and efficacy
of thrombotripsy – ultrasonic acceleration of thrombolysis
Školoudík D.1, Bar M.1, Škoda O.2, Václavík D.3, Hradílek P.1, Šimíčková K.1
1Neurologická klinika FNsP Ostrava-Poruba, 2Neurologické oddělení nemocnice Pelhřimov, 3Neurologické oddělení VNBMA Ostrava |
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Summary:
Occlusion of a supplying or intracranial cerebral artery is the most frequent cause of ischemic stroke.
In vitro and in vivo studies in animal models demonstrated the efficacy of ultrasound waves –
thrombotripsy – in accelerating recanalization of the occludedartery.Theauthors performed ultrasonic
thrombotripsy in 30 patients with acute ischemic stroke, in whom occlusion of an intracranial artery
had been demonstrated. In all patients, therapy was initiated within 6hours from the onset ofsymptoms.
In 9 patients (30 %), a complete recanalization of the artery occurred within 60 minutes after the
initiation of therapy, in 17 patients (57%), a partial recanalization occurred. After 24 hours, complete
recanalization of the intracranial artery was detected in 29 patients (97 %). The authors noted 3
complications – 1 severe (intracerebral hemorrhage) and 2 mild (mild brain edema and a small
hemorrhagic transformation of the ischemic focus). Thrombotripsy seems to be a promising method for
treatment of patients with ischemic stroke. Multicentric studies are presently under way to confirm
this effect.
Key words:
ultrasound, arterial recanalization, stroke treatment, ischemia, thrombolysis
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