Authors evaluate in retrospective study group of 102 children treated in years 1980 – 1996 in PICU v Motol for brain oedema caused by Reye’s syndrome. Input criteria of the group were Reye’s syndrome and ICP monitoring. Epidural way of ICP monitoring was used. Standard therapeutical protocol for treatment of brain oedema as a part of treatment of hepatocerebral syndrome was used. Evaluated group had 102 children, mortality rate was 48%. Greatest incidence was in years 1983, 1984 and 1986. Last case appeared in year 1995. Decrease of incidence is associated with end of using of Acylpyrin in common paediatric practice.

        Key words: Reye’s syndrome – brain oedema – intracranial pressure monitoring – children