The author focused his attention on pituitary adenoma with prolactin hypersecretion - a prolactinoma and its possible therapy. In particular conservative medicamentous treatment of this disease, as well as of other hormonally active pituitary adenomas is a very much discussed problem in retem years. Medicamentous prolactinoma treatment involves administration of drugs from the group of dopaminergic agonists (DA) which are sufficiently effective in cca 90% of patients. In the remaining patients with this diagnosis it is necessary to select other treatment - irradiation with a gamma knife or neurosurgical operation. The most serious symptoms by which a pituitary prolactinoma is manifested is in both sexes compression and damage of the optic pathway, and in women hyperprolactinaemia causes moreover sterility and impairment of the menstrual cycle. In the correct diagnosis of a prolactinoma an important part is played by an accurate differential diagnosis. In selection of DA for medicamentous therapy the incidence of undesirable effects is decisive as well as an adequate therapeutic effect, and last but no least, also economic aspects. DA dosage is individual, depending on the serum prolactin level and reduction of the cize of the adenoma during imaging. In the second part of the paper the author gives an account of treatment of 11 patients with pituitary prolactinomas, two of whom had surgical treatment and the remaining nine are treated conservatively. During therapy none of the patients developed serious undesirable effects nor rezistence to treatment. The achieved results are comparable with similar studies implemented abroad.

        Key words: pituitary adenoma, prolactinoma, dopaminergic agonist, prolactin, bromocriptine