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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 9, p. 878 - 881 |
Diabetes Mellitus in Chronic Pancreatitis and Insulin
Sensitivity Vlasáková Z., Bartoš V., Špičák J. Centrum diabetologie, přednostka prof. MUDr. Terezie Pelikánová, DrSc., Klinika hepatogastroenterologie, přednosta doc. MUDr. Július Špičák, CSc., Institut klinické a experimentální medicíny, Praha, ředitel MUDr. K. Filip, CSc. |
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Summary: Diabetes mellitus as a specific etiological type of disease is a relatively frequent complication of
chronic pancreatitis and is found always after total pancreatectomy. It is not clear whether in the
frequently profound hypoglycaemias of these patients also increased insulin sensitivity may participate.
Data in the literature are not uniform. The objective of the submitted work was to assess
the insulin sensitivity in 10 patients with chronic pancreatitis (confirmed by ERCP) and diabetes
and to compare them with 10 controls and 10 diabetics type 2 treated by diet matched for age and
body mass index. The effect of insulin was assessed by the method of the 3-hour hyperinsulin
euglycaemic clamp (insulin level 75 U/ml, blood sugar level 5 mmol/l) acording to glucose consumption
as glucose Mglu, glucose clearance MCRglu and insulin sensitivity index SI. Patients
with pancreatic diabetes did not differ from controls and type 2 diabetics resp. as regards fasting
insulin, C peptide level and lipid parameters. The groups did not differ as regards the glucagon
level. Patients with chronic pancreatitis and diabetes had a lower insulin sensitivity than healthy
controls.
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