Sinonasal polyps can be divided from the histological aspect into four groups. Oedematous eosinophil polyps, chronic inflammatory polyps, polyps with hyperplasia of the seromucous glands and atypical nasal polyps. The criterion for diagnosis of glandular polyps according to Hellquist is a large amount of glands and glandular ducts in oedematous stroma of the polyp and hyperplasia of glandular structures which may be so marked that it resembles a benign glandular tumour. The objective of the present work was to investigate in patients with permanent purulent nasal secretion the presence of seromucous glands in nasal polyps as well as the concurrent presence of tissue eosinophilia with the presence of glandular structures. The investigated group comprised ten patients with nasal polyps associated with permanent purulent nasal secretion. None of the patients had a positive case-record of acetylsalicylic acid (ACA) intolerance but eight had a positive nasal provocation test for assessment of ASA intolerance. The control group comprised 20 patients with nasal polyps who had a permanent purulent nasal secretion and did not suffer from the syndrome of ASA intolerance. Only in one patient of the investigated group the histological picture corresponded to the glandular type of nasal polyp, in another six the glandular structures were only more numerous. In the investigated group of patients with nasal polyps associated with permanent purulent nasal secretion the glandular structures with permanent purulent nasal secretion the glandular structures were more frequent in seven of ten patients, in the control group the glandular structures were present in six cases of twenty. Seromucous glands were thus significantly more frequent in nasal polyps of patients with permanent purulent nasal secretion. In all 30 patients from the control well as the experimental group more frequent glands were found along with tissue eosinophilia in 15 patients. Thus a more frequent combined incidence of both investigated histological characteristics was not found.

        Key words: nasal polyps, pathology, eosinophilia, seromucous glands.