In 1999, standards for the treatment of ankylosing spondylitis were published by Czech Society for Rheumatology. Anti-TNF treatment has been approved for ankylosing spondylitis in 2003, and therefore the supplement to those standard protocols is being published. Disease characterization, diagnostic criteria, basic conditions for TNF blockers-treatment, the way of use of individual agents and follow-up during the treatment are presented in the paper.

        Key words: ankylosing spondylitis, standard protocols of treatment, biological agents, TNF blockers