Phosphodiesterase inhibitors (amrinone) can be used in the therapy of heart failure in severe sepsis. Their effect is different than effect of adrenergic inotropics effect, but inotropics are used as the therapy of the first choice. Especially the combination of the both groups of drugs is very effective and can be helpful for the circulatory stabilization of severe septic shock. In the case presentation favourable circulatory effect of amrinone is presented in the 19 years old patient with meningococcal severe septic shock.

        Key words: sepsis - heart failure - invasive meningococcal disease - amrinone