The author discusses the etiopathogenesis of portal hypertension and possibilities how to influen- ce it during treatment of acute haemorrhage from varicosities and how to implement primary and secondary prevention. In treatment of acute haemorrhage the author recommends terlipresin, 1 mg every 4 hours. In primary and in particular in secondary prevention he emphasizes the necessity of early administration of beta-blockers.

        Key words: Treatment of acute haemorrhage - Vasoconstrictors - Primary and secondary preven- tion - Beta-blockers - Vasodilatating agents - Combination of drugs.