Difficult weaning from ventilatory support is observed in almost one fourth of ventilated patients. Difficult weaning results in longer ICU stay, while repeated weaning trials can account for a respectable part of the whole ventilatory support time. The aim of the study was to evaluate selected clinical and metabolic markers in patients with different duration of ventilatory support and weaning process. In 37 patients we prospectively monitored following parameters: albumin, pre-albumin, transferin, cholinesterase, CRP, ionized magnesium, phosphorus, myoglobin urine level, and selected clinical parameters (APACHE II, SOFA, Goris score, presence of septic shock, corticoid therapy). According to the length of weaning, patients were divided into two groups: group S, weaning period < days, n = 15 group; L, weaning period ł 3 days, n = 22. Patients in the L group had significantly more advanced age, longer weaning period and total ventilatory support duration; non-significant changes were observed in SOFA score and Goris score. We did not observe significant changes in biochemical markers, which makes its routine monitoring in patients requiring prolonged ventilatory support dubious.

        Key words: mechanical ventilation – weaning from ventilator – multiorgan dysfunction system – biochemical monitoring – nutrition status