Examination of Cerebrospinal Fluid from the View of Free Radicals and Antioxidants in Some
Central Nervous Diseases
Holeček V.1, Racek J.2, Trefil L.2, Rokyta R.3
1Oddělení klinické biochemie Mulačovy nemocnice, Plzeň 2Univerzita Karlova, Lékařská fakulta a fakultní nemocnice, Ústav klinické biochemie a laboratorní diagnostiky, Plzeň 3Univerzita Karlova, 3. lékařská fakulta, Ústav normální, patologické a klinické fyziologie, Praha |
|
Summary:
Free radicals and antioxidantsmay play a role in the etiology and pathogenesis of some central nervous diseases.
The brain tissue is relatively insufficiently protected by antioxidants against the free radical induced damage.
The brain situation may be reflected by the cerebrospinal fluid examination, which has not enough attention. It
seems, that from this point of view subarachnoical hemorrhagy,meningitis, hydrocephalus, Alzheimer’s, Parkinson’s
and Huntington’s diseases,multiple sclerosis and probably schizophrenia should receive a special attention.
Key words:
cerebrospinal fluid, free radicals, antioxidants, CNS diseases, lipid peroxidation
|
